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The methotrexate dosage did not differ between the groups at the start of treatment compared with when the infusion reaction occurred.
Even though a confounder effect in this regard cannot be excluded, disease activity (as defined by the laboratory parameters haemoglobin, leucocytes and ESR) per se seems to be of relevance to the development of PP, because the naproxen dosage did not differ significantly between the two cohorts of children with and without PP.
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In the postpartum period, prednisone daily dosages did not differ between GC-S and GC-I patients.
More importantly, the absolute expression levels for dosage-sensitive genes did not differ from that of dosage-insensitive genes.
However, we did not attempt to balance the background characteristics of the patients according to each regimen, because treatment dosages and schedules did not differ between the lines.
Consistent with this hypothesis, the fractions of singletons and nonsingletons for nonrecessive dosage-sensitive CNVs did not differ from that of overall CNVs (fig. 5 B ). Another category in which the fraction of nonsingleton increased significantly consists of dosage-insensitive CNVs, most likely due to the low penetrance of CNVs having little or no effects on phenotypes.
The average bursting pressure rose slightly with decreasing dosage of carprofen but did not differ significantly between groups.
Univariate ANOVAs for dosage and days post injection did not differ significantly across the age groups (p > 0.10).
The mean ± standard deviation of age, gender ratio, years since diagnosis and dosage of prednisolone before study entry did not differ significantly between the SR and SS groups (Table 2).
As expected for autosomal or pseudoautosomal genes, their relative gene dosage ratios were very close to, and did not differ significantly from, the expected value of 1.0 (t-test, P = 0.08).
The two groups did not differ significantly in CPZ dosage (Table 5).
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