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As a result, a need to identify an acceptable, soluble salt for clinical dosage development arose for researchers.
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Strangely, under higher dosages, development of dependency is listed.
Dosage form development involves design and development of a product with a defined target product quality profile, and a defined manufacturing process.
One of the most critical elements of dosage form development is to apply a unified view of formulation and process development.
Polymeric excipients possessing an established profile for commercial dosage form development were selected.
The designed system offers a resource sparing primary screen for drug excipient chemical compatibility for solid dosage form development.
The model is a potentially useful in silico analysis tool that can be used for capsule dosage form development in accordance to quality by design (QbD) principles.
Dosage form development should focus on overcoming the limitations facing oral peptides delivery as degradation by proteolytic enzymes and poor absorption in the gastrointestinal tract (GIT).
These materials can potentially be used for design of novel mucoadhesive dosage forms, development of solid drug dispersions and solubilisation of poorly soluble drugs, encapsulation technologies, preparation of nanoparticles, hydrogels, in situ gelling systems and electrically erodible materials.
Excipients, although generally regarded as inert components, are of great significance in terms of solid dosage form development and any variation in the material attributes may impact drug product performance.
The use of key parameters estimated from the modeling of dissolution and de-agglomeration profiles provides a useful tool in dosage form development of formulations of poorly water soluble drugs.
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