More prospective, longitudinal observational studies are warranted to evaluate the relation between dosage and choice of different statins in treating non-cardio-embolic stroke patients, to determine how to prevent END, and to improve neurologic outcome.
Antimicrobial stewardship (AMS) programs aim to provide assistance with optimal choice, dosage, pharmacokinetic pharmacodynamic (PK/PD) characteristics and duration of antibiotics in order to reduce costs, adverse events and the development of resistance [40].
Methodological issues also need to be carefully considered: for instance, dosage, treatment duration, choice of outcome measures, populations under study, and concomitant therapy [ 155].
Antimicrobial prescriptions were globally considered inappropriate if any of the assessed criteria appeared unacceptable, according to indication or antimicrobial choice, dosage errors, and duration of treatment.
Although antituberculous medications used to treat humans are thought to be effective for treating active TB in elephants, little evidence is available to guide decisions regarding medication choice, dosage, length of treatment, or assessment for cure.
The appropriateness of empirical treatments prescribed by treating physicians (physicians of the primary service) was assessed and treatments were classified as adequate (agree with antibiotic choice, dosage, dosing interval and duration of treatment) or inadequate.
As a non-interventional study, there was no fixed study visit schedule, and insulin choice, dosage, titration, funding and concomitant oral agent therapy were according to usual local practice.
22 24 Researchers have previously suggested that doctors remain in a challenging position regarding the use of antibiotics, 9 if they are required to assume all responsibility for decisions about choice, dosage, duration, in addition to being often under-informed about antibiotics in contexts where antibiotic choice is perceived as a peripheral rather than core clinical decision.
Also identified was a lack of capacity to convey advice and expertise in antibiotic use in their current role, particularly the challenges associated with not always being 'at the bedside' to give advice at the point of initiation of antibiotics (ie, regarding issues of choice, dosage, duration and mode of delivery).
The optimal choice and dosage of anti-platelet agent is unclear, but dosages of low-dose aspirin appear to be important, and higher doses in the low-dose range may be more efficacious.
