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These results, obtained by gene copy dosage, are consistent with those deduced from earlier cytogenetic (Vogelstein et al, 1988; Mitelman et al, 1997) and loss of hetereozygocity (LOH) studies on the 18q21 region (Laurent-Puig et al, 1992; Jen et al, 1994; Martínez-López et al, 1998; Jernwall et al, 1999; Watanabe et al, 2001).
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The dosage is consistent with recommendations from a meta-analysis of exercise interventions in reducing falls [ 14].
Dosage was consistent with current guidance (BNF, 64): infliximab (in combination with methotrexate) dosage is 5 mg/kg and the model assumes an average weight of 75 kg.
These dosages are consistent with the concept that migraine is a particular pain characterized by neuronal hyperexcitability and that migraine should be treated with specific drugs at dosages that could be sub-analgesic, but are antihyperalgesic [7].
The concordance between genotypes and dosages is consistent with the potential of the signal as a candidate (Table 3).
Our daily dosages were consistent with those employed to treat epilepsy in rodents (3 5 mg/daily 14, 15), while simultaneously falling within the dosing range prescribed to children or infants (100 250 mg/kg 16) and those used in our earlier studies with SSADH-deficient patients (40 100 mg/kg per day 7).
The daily dosages of these medications are consistent with those recommended in product labeling information in Spain.
Although the methods of administration and the dosages were unrelated, these findings are consistent with those reported in the present study.
Since males exhibit two copies of the Z chromosome and females only one, these results are consistent with inefficient dosage compensation of the Z chromosome genes in the chicken [ 7, 8].
Dosages were comparable to the recommended national reference dosages for plain films [ 50] and are consistent with a cancer risk of between 1 10,000 and 1 100,000 [ 51].
Therefore, the results are consistent with the inverse dosage effect being caused by a single gene copy number change in the genome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com