Sentence examples for dosage approach from inspiring English sources

Thus, we developed an alternative approach, the epigenetic-genetic (EGG) chromosome dosage approach, with potentially wider population coverage.

Here we apply this epigenetic-genetic (EGG) chromosome dosage approach to detect Edwards syndrome (trisomy 18) in the fetus noninvasively.

In conclusion, we have shown that by using an informative SNP allele as the genetic reference baseline, the EGG chromosome dosage approach could be applied to the prenatal diagnosis of trisomy 21 for both male and female fetuses.

As a proof-of-concept study, we have demonstrated that the epigenetic-genetic chromosome dosage approach can be applied to the prenatal diagnosis of trisomy 21 for both male and female fetuses.

Detection of fetal trisomy 21 (T21) has been demonstrated by an epigenetic-genetic chromosome dosage approach where the amount of hypermethylated HLCS in maternal plasma is normalized using a fetal genetic marker on the Y chromosome as a chromosome dosage reference marker.

We have recently proposed a novel epigenetic-genetic chromosome dosage approach for fetal trisomy 21 detection using a fetal epigenetic marker, the putative promoter of the holocarboxylase synthetase (HLCS) gene (NM_000411) on chromosome 21, and a fetal genetic marker, the zinc finger protein, Y-linked (ZFY) gene (NM_003411) present on chromosome Y [29].

This fraction is required in non-invasive prenatal diagnosis for the calculation of the relative chromosome dosage for assessment of fetal aneuploidies [ 32] or relative mutation dosage approaches for single-gene disorders such as sickle cell anaemia [ 33], as well as tumour diagnostics for monitoring of cancer-associated copy number variations [ 10].

However, only one group has used this assay on maternal plasma samples for NIPD of trisomy 21 through the epigenetic-genetic chromosome-dosage approach [ 78, 79].

Two different approaches have been developed, the digital RNA-SNP strategy and the digital relative chromosome dosage (RCD) approach.

Overall, our study uncovered a target of Tbx1 with critical developmental roles, so highlighting the power of the dosage gradient approach that we used.

With prolonged survival and tumor recurrence, serious problems emerge, including accumulated drug dosages that approach the upper limit of safety, therapy-related toxicity, and drug resistance.