Six claims (8%) qualitatively praised the drug's safety profile, 3 claims (4%) mentioned dosage advantages, and one claim was about a financial incentive.
Hence, the duplication by itself does probably not confer a direct benefit to the evolved cells, in contrast to duplications that result in a gene-dosage advantage [ 1- 3].
Duplicates can be retained with the same function if increased dosage gives selective advantage (Spofford 1969; Otto and Whitton 2000; Hakes et al. 2007).
As part of the focus group participants were shown a 3 minute video clip on amitriptyline medication [ 24] (which can be prescribed before bedtime for fatigue and pain in chronic musculoskeletal conditions), including how it works, dosage and its advantages for managing chronic nerve pain.
Dose modification in the presence of different protease inhibitors (such as atazanavir and lopinavir) can be seen as an advantage (lower dosage required) or a disadvantage (complexity of dosage).
Therefore, also the genomic localization of genes has the potential to influence the expression level via gene dosage regulation; another possible advantage is gene redundancy, including the possibility to mutate the genome under unfavorable conditions while keeping the wild-type information in other copies.
Following WGD, tetraploidy was followed by the removal of duplicate genes except for those (such as ribosomal protein genes) for which an increase in gene dosage produced a selective advantage in the sugar-rich environments provided by the emergence of the flowering plants 100 million years ago.
Modified release dosage forms offer definite advantages over conventional release formulation of the same drug.
Treatment adherence may be enhanced when the combination therapy is in a single dosage formulation, with obvious advantages for the practicing physician and patient (Williams et al. 2004).
This bias in favor of the MM over Mm and mm genotypes suggests that, although the presence of m-alleles in the genome confers beneficial sequence diversity and gene-dosage modulation, functional advantages generally accrue to the M-alleles over m-alleles at most of the base positions in the genome.
This dosage form presents the clinical advantage of less frequent dosing, with increased quality of life for patients.
