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Subsequent dosage adjustments were allowed while maintaining the blind.
Between 20% and 46% of prescriptions requiring dosage adjustments based on renal function are inappropriate.
Direct oral anticoagulants work in a way that is similar to warfarin, but don't need monitoring or special dosage adjustments.
Dosage adjustments after large local reactions are commonly instituted despite literature that suggests individual large local reactions do not seem to predict subsequent systemic reactions.
The median number of dosage adjustments to attain normal concentrations was 1 (range 0-4 adjustments).
Dosage adjustments were made in 15 patients, in 12 because of anemia or neutropenia.
The need for dosage adjustments based on age, gender and obesity appear unnecessary.
Twentypercentt of medications implicated with ADEs required dosage adjustments, and 48% of ADE-related medications were discontinued.
Because telavancin is extensively cleared by the kidneys, dosage adjustments will be required in patients with moderate to severe renal impairment.
Volatile anaesthetics such as isoflurane are preferred as the duration and depth of anaesthesia can easily be controlled, and response to dosage adjustments is immediate.
The principal focus is on recently developed concepts in infection management and in antibiotic use, bearing in mind that in these patients the pharmacokinetics of antibiotics are altered, affecting renal clearance and requiring dosage adjustments.
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CEO of Professional Science Editing for Scientists @ prosciediting.com