The lack of water during summer periods of drought or winter periods of freezing, as well as annual changes in the duration and intensity of light, particularly at high latitudes, are other environmental factors that can induce dormant states.
Here, we present an extended modeling concept for the growth and decay of microorganisms that explicitly accounts for their ability to switch between active and dormant states.
Dormancy has been implicated with drug resistance, while enforced dormancy has also been seen as a radical method to control cancer, and engineering of dormant states has emerged as a novel clinical strategy.
P. falciparum dormant states are essentially refractory to antimalarial action [6] presumably due to its low metabolic activity status.
Our data showing that BrdU can indirectly induce activation of HSCs, provides an elegant explanation for this phenomenon [2] which additionally raises the possibility that the d-HSCs can reversibly switch between active and dormant states (Figure 1).
Microarray analysis showed that RGL2 up-regulates several genes associated with dormant states of seeds.
