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We have identified region-specific functional abnormalities in dopaminergic function, which may help better account for the symptoms of ADHD.
Mesocortical dopaminergic function and human cognition.
Altered prefrontal dopaminergic function in chronic recreational ketamine users.
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia.
Human inmmunodeficiency virus-1 Tat protein and methamphetamine interact synergistically to impair striatal dopaminergic function.
Brain presynaptic dopaminergic function can be assessed using 18F-DOPA positron emission tomography (PET).
Recent research has shown that pharmacological enhancement of dopaminergic function increases an optimism bias in humans.
The results demonstrate a link between aging, dopaminergic function and dedifferentiation in the hippocampus.
Roy, K. et al. Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders.
These results provide new evidence that striatal dopaminergic function is related to PFC-dependent functions, particularly brain activation and behavioral performance during WM tasks.
These data confirm the utility of 18F-DOPA PET in assessing dopaminergic function in the striatum and select extrastriatal areas but highlight the limitations in using this approach to measure dopaminergic function in low uptake extrastriatal brain areas.
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