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For example, miR-132 modulates the dopamine neuron differentiation while miR-124 regulates neurite outgrowth during neuronal differentiation (Yang et al., 2012; Yu et al., 2008).
Fig. 1 Calibration of dopamine neuron model.
Data showed that the expression levels of genes related with dopamine neuron system were altered.
Intrastriatal GDNFv also protected midbrain dopamine neuron function in 6-hydroxydopamine-lesioned rats.
The strategy is to selectively inactivate mitochondrial transcription factor A (Tfam) in dopamine neurons thus mimics PD progression particularly for dopamine neuron degeneration.
Early clinical trials designed to treat Parkinson's disease by transplantation of fetal tissue containing dopamine neuron precursors yielded promising results, but the approach retains several limitations.
The role of the VTA dopamine neuron in negative motivation has also been noted.
However, the exact role of the VTA dopamine neuron in negative motivation is not fully clear.
This strongly suggests the diversity of the VTA dopamine neuron population [24], [25].
The temporal distribution of dopamine neuron firing can also change across long delays [103].
In an organotypic slice model, angiogenic factors maintain vascular structure and increase the density of dopamine neuron processes.
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