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By using mice lacking the dopamine transporter (DAT-KO mice) [9], [11], we have developed a model of acute dopamine deficiency, DDD mice (dopamine-deficient DAT-KO mice) [12], [13].
Dopamine deficiency is a key component of Parkinson's but the underlying cause is a complex set of interactions triggered by inflammation in the autoimmune system.
The dopamine deficiency can be seen in these images.
Ratios, representing the dopamine deficiency, that are used for the diagnosis (bottom).
RCC patients frequently present with arterial hypertension due to various causes, including intrarenal dopamine deficiency.
This could be the result of a dopamine deficiency in the striatum and an increased turnover of DOPAC/DA in the brainstem.
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Normalization with MPH of reduced activation in typical frontoparietal regions of saliency processing and performance monitoring is consistent with the dopamine-deficiency hypothesis of ADHD given that dopamine agonists enhance stimulus salience (73).
Dopamine transporter deficiency syndrome remains under-recognized and our data highlights that dopamine transporter deficiency syndrome should be considered as a differential diagnosis for both infantile- and juvenile-onset movement disorders, including cerebral palsy and juvenile parkinsonism.
We identified eight new patients from five unrelated families with dopamine transporter deficiency syndrome.
Patients presenting with parkinsonism dystonia or a neurotransmitter profile characteristic of dopamine transporter deficiency syndrome were recruited for study.
Dopamine transporter deficiency syndrome is an SLC6A3-related progressive infantile-onset parkinsonism-dystonia that mimics cerebral palsy.
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