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Dopamine availability is vital for prefrontal functions.
Kumar, A. M., Ownby, R. L., Waldrop-Valverde, D., Fernandez, B. & Kumar, M. Human immunodeficiency virus infection in the CNS and decreased dopamine availability: relationship with neuropsychological performance.
The laminar imbalance of COMT expression, which presumably leads to imbalance of dopamine availability at the synaptic level, may contribute to dysregulation of pyramidal neuronal circuitry in the prefrontal cortex, albeit to a relatively small degree.
The functional variant Val158Met in the coding sequence of COMT gene is involved in the modulation of dopamine availability in the prefrontal cortex in both clinical and general population samples.
As both, the COMT genotype and physical exercise have been shown to influence dopamine availability and as changes in dopamine metabolism seem to play a key role in cognitive aging, the aim of this study was to analyze the association of the COMT gene polymorphisms with the relationship between fitness and cognition.
To probe striatal dopamine availability, animals were challenged with the dopamine D2 receptor agonist apomorphine.
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In this context, his group has used positron emission tomography scanning to examine the effect of cigarette smoking on glucose metabolism, dopamine receptor availability, nicotinic acetylcholine receptor availability, and a marker for neuroinflammation.
Putamen-midbrain functional connectivity is related to striatal dopamine transporter availability in patients with Lewy body diseases.
Zald DH, Cowan RL, Riccardi P, Baldwin RM, Ansari MS, Li R et al. Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humans.
Addolorato, G. et al. Deep transcranial magnetic stimulation of the dorsolateral prefrontal cortex in alcohol use disorder patients: effects on dopamine transporter availability and alcohol intake.
Increased novelty seeking has been associated with increased risk for substance abuse and dependence53, 54 and with reduced midbrain dopamine receptor availability.55 It is possible that novelty seeking may not be a strong risk factor for obesity because, unlike drugs of abuse, humans are exposed to food on a daily basis.
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