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ICAM-1/VCAM-1-expressing stromal organizers, follicular dendritic cells, lymphatic endothelium, and HEVs in these structures are of donor origin, while all hematopoietic cells are host derived.
Host-reactive lymphocytes of donor origin are the cells responsible for the "alloimmune" attack.
The pathology of the PTLD in all cases was donor origin, EBV positive, diffuse large B-cell lymphoma.
In those patients with a marrow donor of opposite sex the alveolar macrophages were shown to be of donor origin.
The donor origin of the PTLD was determined using short tandem repeat analysis, and B- and T-cell clonalities were evaluated by polymerase chain reaction.
PTLD was of host origin in 2 patients who failed engraftment and of donor origin in the remaining 3 patients who had complete engraftment.
In 26 children (5 recipients of HLA-identical marrow and 21 recipients of haploidentical marrow) between22 percent and 100 percent of B cells were of donor origin.
After mild graft-versus-host disease developed, studies revealed that more than 99% of his CD3 lymphocytes and 50% of his CD19 lymphocytes were of donor origin, whereas granulocytes and monocytes remained of recipient origin.
At the time of the most recent evaluation, all but 4 of the 72 survivors had normal T-cell function, and all the T cells in their blood were of donor origin.
We found no muscle of donor origin following these 2 injections.
The present investigation reports the fast generation of donor-derived spermatozoa and production of normal offspring of donor origin.
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