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When Congress enacted the ban, most people in the organ donor field found financial incentives unethical.
Through the CoMSIA combined five fields, we found that the H-bond donor field is important as well as the steric and electrostatic fields.
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The electrostatic, hydrophobic and H-bond donor fields play important roles in the models.
The best CoMSIA model included both electrostatic and hydrogen bond donor fields (CoMSIA-ED model) and provided the best statistical results with a highest Q2 value of 0.901.
The factors affecting activity were analyzed carefully according to standard coefficient contour maps of steric, electrostatic, hydrophobic, acceptor and donor fields derived from the CoMFA and CoMSIA.
The q2cv and r2ncv values for the selected CoMSIA model comprised four descriptors steric, electrostatic, hydrophobic and hydrogen bond donor fields were found to be 0.535 and 0.951, respectively.
Similarly the best predictive CoMSIA model was derived with q2 of 0.508, noncross-validated r2 of 0.894 and standard error of estimate of 0.197, comprising steric, electrostatic, hydrophobic and hydrogen bond donor fields.
A more dramatic difference between Class I and Class II compounds appears in the CoMSIA hydrogen bond acceptor and donor fields (Figures 3C and 3D).
Resource: An MSF initiative last year aimed at strengthening links between donors, field staff and patients.
An MSF initiative last year aimed at strengthening links between donors, field staff and patients.
Advocacy and negotiation instrument Instrument to align donors Field planning Costing database Advocacy and negotiation instrument: to advocate and negotiate for more funding for the (decentralized) health districts Negotiations with the Ministry of Finance were better informed by the DR Congo costing database.
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