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The remaining marker contained null alleles and was excluded from the pollen donor analysis.
Combined donor analysis does not well support the hypothesis that microbiome community function is best described as an emergent property of community structure.
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Cross-donor analysis supports the hypothesis that microbiome community function is an emergent property of community structure.
To look deeper into this dataset and seek potentially biologically relevant molecular mechanisms of dysbiosis, we turn to the more stringent cross-donor analysis.
The set of microbiome features used in the cross-donor analysis is taken from the most predictive feature subsets from the previous results, based on the combined Donor A and B data (Fig. 6).
While this analysis successfully demonstrated that, for the cross-donor analysis, emergent properties of microbiome community are more predictive than the community structures themselves, there is much additional work that can be anticipated.
Such aggregation would easily allow for comparative cross-donor analysis as by applying the same analytical approaches, it will be possible to attribute each specific donor's financial contributions to strengthening each element and component of the health system in a given country.
Despite the fact that the cow DNA samples in our GWAS were from diverse academic and industry donors, analysis of USDA's historical Holstein pedigree data revealed that the 1,654 cows were all related when traced through approximately 10 to 15 generations (back to the 1930's) of ancestors (Additional file 2: Figure S2).
When analysing the effects of cross type (within/between populations) and the region from which the recipient and donor originated (Analysis 2), we found a significant effect of cross type (Table 2).
Donor response analysis was also compromised by a smaller sample size (n=48).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com