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Somewhat counter-intuitively, we find that mechanisms yielding Pareto dominated outcomes may in fact enhance the overall performance of the system, and we provide a justification of these results by interpreting these inefficiencies as externalities being internalized.
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That ordering is extremely interesting as it suggests that best practices, not race, dominate outcomes.
These included several trials that primarily aimed to improve symptoms or functional status, trials that tested interventions with a considerable potential for causing harm (mainly bleeding) that were not meaningfully measured, and trials with composite outcomes that were dominated by outcomes of questionable importance to patients.
In addition, composite outcomes in many trials were often dominated by outcomes that were not immediately important to patients.
In this cohort of advanced tumours (89% were muscle invasive), CSM dominated survival outcomes, so that OCM contributed to only 8 27% of deaths at 5 years.
In 52 of these 92 trials (57%) less than half of the events were attributable to patient important outcomes that is, the composite outcome was dominated by intermediate outcomes such as physiological, biochemical, or surrogates.
The Finger Lakes, with more than 50 wineries, proportionately dominated the outcome.
In galley warfare, sheer power dominated the outcome, and maneuver of numerous small ships, much as on land, contributed to its concentration.
*For comparison against trials where primary outcomes were not dominated by patient important outcomes.
Some countries thought that France, then holding the rotating E.U. presidency, was trying to dominate the outcome.
It should be said that, in order to achieve victory, willpower and courage must always accompany tactical art and science and often dominate the outcome of battle.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com