While ACERs are useful background information, rank ordering of interventions must be done on the basis of incremental cost-effectiveness ratios (ICERs) after removal of dominated interventions [ 33].
We excluded dominated interventions (which had a higher mean overall change in cost to the health service and lower mean QALY gain than another intervention) and interventions that were subject to extended dominance (as combinations of other interventions could provide a greater benefit at equivalent cost).
Cost, effects, and cost effectiveness of interventions are listed in tables 6 and 7 for sub-Saharan Africa and South East Asia and are rank ordered on the basis of their incremental cost effectiveness ratios (the tables do not include dominated interventions that are more costly or less effective than other interventions).
Dom'd, dominated (Treatment costs more and is less effective than the other intervention); Ext Dom'd, extendedly dominated (ICER is greater than that of the more effective intervention); ICER, incremental cost-effectiveness ratio; QALY, quality-adjusted life years.
There is little doubt that current interventional procedures and future developments in image-guided interventions will dominate treatment in medicine [10].
It can be assumed that the current interventional procedures and future developments in image-guided interventions will dominate treatment in medicine in the future.
Comparison of the mean change in cost and mean QALY gain (table 1) across the four intervention groups showed that dietary intervention alone was dominated by dietary intervention plus quadriceps strengthening exercises.
Eleven interventions (5%) were more costly and less effective than their comparators and were therefore dominated, 21 interventions (8%) were both more effective and cheaper than their comparator and thus dominant.
The facilities intervention was dominated by the community intervention and the combined intervention, suggesting money would be better spent first on scaling up the community intervention and then the combined intervention.
The ICER ranged from $1180-$1180-$1400ALY gained when the utility weight associated with active TB disease was varied between 0.9 and 0.5; if mortality among those developing TB disease increases above 14%, the Standard algorithm was found to dominate the Intervention.
