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Available evidence demonstrates that the two viruses can inhibit each other simultaneously; the chronology of infection has a role in determining the dominant virus; and HBV and HCV can alternate their dominance [ 30– 30].
Overall, the available evidence demonstrates that both viruses can inhibit each other simultaneously; either virus can play a dominant role; both viruses have the ability to induce seroconversion of the other; the chronology of infection has a role in determining the dominant virus; and HBV and HCV can alternate their dominance [ 8].
"Things could change in the next week or the next month, and we could end up with a mild season, or with a different dominant virus".
Viral genotype displacement events are characterized by the replacement of a previously dominant virus genotype by a novel genotype of the same virus species in a given geographic region.
Later samples also indicated an IIV-6-like virus as the dominant virus in collapsing colonies (88 percent of IIV peptides).
However, even in these years of semiannual peaks, the dominant virus in each peak was the same subtype A(H3N2) (Figure S3).
Similar(22)
In addition, we have found that the dominant virus-specific CD8+ T-cell populations were either perforin− and IL-2−, or perforin+ and IL-2−, or IL-2+ and perforin− (Figure 6B).
Our simultaneous evaluation of multiple epitope-specific responses representing the dominant virus-specific T cell responses as determined by IFN-γ revealed heretofore unappreciated epitope-specific differences in CD8+ T cell differentiation, comparing very distinct study populations at the extremes of viral control.
If the VEM method were performed using next-generation sequencing technologies, coverage of the dominant viruses would be much higher, and many more viruses present at lower abundances would be identified.
This is the cornerstone of our novel therapeutic paradigm which enables targeting, not only of dominant viruses, but also newly emerging virus populations which evolve as a result of immune pressure.
The dominant viruses identified in this study were Tomato yellow leaf curl virus (TYLCV) and Cucurbit leaf crumple virus (CuLCrV), which are both whitefly-transmitted begomoviruses that have been introduced to Florida since the arrival of the silverleaf whitefly in the late 1980's [49], [50], [51].
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