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Many separation technologies routinely filter out non-target analytes, thus eliminating possibility of understanding their connection to dominant target analytes in an environmental sample.
Secondly, the one isolated dominant target assumption is not indeed needed for the proposed method, which makes the proposed method can be widely used in most practical condition.
Study design: Defective subviral particles of HCMV, termed Dense Bodies (DB) contain the dominant target antigens for humoral and cellular immune responses elicited during natural infection.
In AY trials, interference arises from expectancy established by the target cue, while in BX trials interference arises via a dominant target response bias to the probe.
For paramyxoviruses, the majority of virus-neutralizing antibody is directed towards these two envelope glycoproteins with the attachment glycoprotein serving as the dominant target antigen [20], [21], [22].
Previous studies in clade B infection as well as limited studies in clade C infection have shown the HIV-1 Gag protein to be the dominant target of virus-specific CD4+ T cell responses [18], [20].
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Each trial began with 60sec of adaptation to a stationary version of the non-dominant target (dominance was based on subjects reports in experiment 3 red gratings in both cases).
Fig. 6 Illustration of residual RCM in the presence of two dominant targets.
However, RSF radar suffers from the sidelobe pedestal problem, which results in small targets being masked by noise-like components due to dominant targets [29].
For example, when two dominant targets are located in the scene, the signal after coarse range focusing is shown in Fig. 6.
However, some individuals achieving control of HIV during natural infection seem unique in their dominant targeting by cellular immune responses of conserved regions of HIV that, if mutated, exact a substantial impact on viral replicative capacity, or fitness.
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