Sentence examples for dominant regulators from inspiring English sources

Also, the proto-apicomplexan ancestor genome encoded many proteins with canonical DNA Binding Domains (DBDs), suggesting that apiAP2 proteins were major, but not dominant, regulators of gene expression, and that the dominance of apiAP2 came after subsequent loss of proteins with DBDs during and after transition to apicomplexans.

Besides, some TFs were considered as dominant regulators because of their frequently changed activities: such as RAV1, which widely regulates growth and developmental genes in Arabidopsis [ 56].

We have defined R-spondins as dominant regulators of the ISC niche with Wnts playing a more permissive role using lineage tracing, bioengineered Wnts and single cell RNA-seq approaches (Yan et al., Nature, 2017a; Janda et al, Nature 2017b).

We propose a novel technique that constructs gene regulatory networks from DNA microarray data and gene protein databases and then applies Mason rule to systematically search for the most dominant regulators of the network.

Members of the NF-κB family of transcription factors function as dominant regulators of inducible gene expression in almost all cell types in response to a broad range of stimuli, with particularly important roles in coordinating both innate and adaptive immunity.

The biological significance of canalizing functions is based on the existence of dominant regulators.

Sun, M. et al. Collagen V is a dominant regulator of collagen fibrillogenesis: dysfunctional regulation of structure and function in a corneal-stroma-specific Col5a1-null mouse model.

Consistent with previous investigations of odontoblasts, NFI-C also induced MET in breast cancer cells via upregulation of KLF4 and E-cadherin and down-regulation of Slug, a dominant regulator of EMT initiation.

The algorithm then recommends the identified dominant regulator genes as the best candidates for future knock-out experiments.

Mutation of FasL in either compartment interferes with the autoimmune process and prevents onset of diabetes, but FasL expressed in the hematopoietic compartment is the dominant regulator of T-cell homeostasis.

These genes are regulated in an age- and tissue-specific fashion by PEITC with different modes of actions: Following PEITC treatment, CAR appears to be the dominant regulator in CYP2B10 induction, whereas activation of both CAR and Nrf2 is associated with UGT1A1 induction.