According to Cobanoglu et al., it is now widely acknowledged that the single target paradigm (one protein/target, one disease, one drug) that has been the dominant premise in drug development in the recent past is untenable.
It is now widely acknowledged that the single target paradigm (i.e. one protein/target, one disease, one drug) that has been the dominant premise in drug development in recent past is untenable as both drug-like compound (ligand) and target protein can be promiscuous [1, 2].
And yet, when the dominant psychological premise of society is fear, how can people access essential factors like openness, risk-taking and trust?
Remember that in the on-premise model, the dominant way software is used today, the customer installs the software on their computers, which they control nothing is shared and there are many versions of the software that must be managed by the customer.
The dominant paradigms in leadership theory are premised on seeking stability and avoiding uncertainty.
Created by an Arlington based company called Incando, Pickle is based on the premise that email is the dominant way that multimedia is shared and thus should be the basis of media sharing systems.
The major premise of this approach is that introducing dominant mutant alleles of generic transcription-related proteins can reprogram gene networks and cellular metabolism.
The fundamental premise to this concept is that most dominant oncogenes are able to sustain at the same time both pro-survival and pro-apoptotic signals (Sharma and Settleman, 2007).
One of the central premises of biogeography is that climate exerts a dominant control over the distribution of species [ 63, 64].
Accurate education must establish the premise that cultures and races other than the dominant are full and complete and are not something flawed or of lesser value than dominant culture or race.
