These differing trends between age groups have resulted in a marked change in the shape of the age incidence curve for cervical cancer over time, such that the dominant peak in incidence is now below 40 years of age.
According to Global Cancer Statistics [ 19], NPC is a male-dominant disease with incidence rates usually 2too 3 times lower in females.
NF1 is an autosomal dominant disease with an incidence of 1 2500 3000.
Von Recklinghausen's diseases or neurofibromatosis type 1 is characterized by autosomic dominant inheritance and an incidence of about 1 in 3000 [ 23].
HD is inherited in an autosomal dominant fashion with an incidence of 3 10 in 100 000 in populations of Western European descent.
5, 7, 8 Epidemiological data shows NF1 to be a relatively common autosomal dominant disease with birth incidence estimates ranging from 1 in 2,500 to 1 in 3,000 live births.
Atopic dermatitis (AD) is a chronic relapsing skin disease that is manifested by Th2 dominant hyperimmune disorder, the incidence of which has rapidly increased especially in the industrialized countries [ 1, 2].
The role of Shh signaling pathway in medulloblastoma tumor development had its origins in the Gorlin syndrome, also known as the basal cell carcinoma syndrome, an autosomal dominant disease with an incidence of about 1 in 50,000 live births.
In the DPP, for example, weight loss was reported to be the dominant factor in diabetes incidence reduction in a high-risk population, to the extent that 5 kg lost was estimated to result in a 55% reduction in incidence over 3 years' follow-up [ 37].
The majority of mutations affecting the gene encoding human fibrillin-1, FBN1, result in Marfan syndrome (MFS), a common (1 5000 incidence), autosomal dominant disorder of the fibrous connective tissue with highly variable clinical manifestations characterised by skeletal, ocular and cardiovascular defects.
