Sentence examples for dominant elimination from inspiring English sources

A similar triphasic decline as was seen for ALX-0061 walsolso described for TCZ, whereby the rapid terminal elimination phase could be attributed mainly to target-mediated drug elimination due to IL-6R binding, which was saturated at high drug levels resulting in a lower overall clearance dominated by a linear non-saturable clearance (dominant elimination phase) [ 36].

Further increase in temperature (to 65 °C) resulted in a decrease in activity and M n as a consequence of dominant elimination reaction.

Pharmacokinetic parameters were calculated using non-compartmental analysis i.v. = intravenous; t1/2, dominant = dominant elimination half-life; t1/2, terminal = terminal elimination half-life; AUCinf = area under the concentration-time curve from time zero to infinity; CL = total body clearance; Vss = volume of distribution at steady state.

The dominant elimination half-life of ALX-0061 increalongalong with the dosage (1.7 days after 0.4 mg/kg ALX-0061 to 6.6 days after 10 mg/kg ALX-0061), and the drug exposure increased more than dose-proportionally (Table  2, PK parameter AUCinf).

In contrast, the PK profiles of ALX-0061 showed a triphasic decline: a distribution phase was followed by a dominant elimination phase and a more rapid terminal elimination phase, and after increasing the dose from 0.4 to 10 mg/kg, the estimated clearance of ALX-0061 decreased (9.00 to 24.8 mL/ day/kg)) compared to its monovalent anti-IL-6R domain.

The elimination of dominant Cretaceous groups allowed other organisms to take their place, spurring a remarkable series of adaptive radiations in the Paleogene.

In abandoned agricultural fields, community composition changes rapidly when a field is plowed, and is thought to reflect a relaxation of competition due to the elimination of dominant species which take time to re-establish.

Taken together, these data strongly suggest that inactivation or elimination of dominant monoclonal populations of pathogenic allergen-reactive T cells would modify beneficially the immune response to allergen and observed clinical phenotype.

This supports the concept that CD8+ T cells play a dominant role in tumor elimination by directly killing tumor cells or by the secretion of cytokine or chemokines that have antitumor effects and recruit other adaptive or innate immune components.

Diplontic selection, in which cell lineages with greater vigor outcompete slower growing lineages within or between meristems on the same plant (Klekowski 2003), provides a mechanism for the elimination of dominant, deleterious somatic mutations and the fixation of novel beneficial mutations in clonally propagated cultigens (McKey et al. 2010).

Collision induced dissociation experiments of the alkoxo [W3S4 dmpe)2(O)(OCH2CH3)]+ tungsten (IV) cation reveal that aldehyde elimination is the dominant reaction pathway.