Sentence examples for dominant active from inspiring English sources

This sequence mimics the Q to L mutation seen in Ras and other Rab that confers a loss of GTPase activity (the dominant active phenotype).

Growth inhibitory effect of EZH2 small interference RNA (siRNA) was reversed by dominant active β-catenin, indicating that EZH2 activates wnt signaling to promote gastric carcinogenesis.

However, the precise mechanisms underlying the enhancement of IFN activity by the expression of a dominant active mutant of IRFs in cells replicating HCV remain unknown.

In addition, the conditional induction of a dominant active form of MAP kinase kinase 6 (MKK6) efficiently induced the activation of human LCs [23].

The functional activity of these variant ERα proteins can be negative, dominant negative, or dominant active on ERα target genes.

They are the dominant, active, protective members of their communities.

Ectopic activation of Hedgehog activity in PDCs was obtained either through expression of a dominant-active version of GLI2 [41] or a dominant-active form of Smoothened (SmoA1).

Likewise, over-expression of the Gli3 dominant-active form in developing chick embryos leads to induction of Bcl2 gene [13].

In contrast, ectopic expression of dominant-active ROCK culminated in a substantial increase of MLC2 phosphorylation at actin bundles (Figure 2B).

Dominant-active (VP16 fusion) and -negative (truncation at amino acid 403 of hRAR) retinoic acid receptors cloned into pCIG were provided by S. Sockanathan and T. Jessell.

By examining cell morphology under microscope, we found that ectopic expression of dominant-active ROCK released cells from DLC1-induced cytoskeletal collapse and cell shrinkage.