We demonstrate that, in the human ventricles, the spatial location of the arrhythmogenic substrate yields a hierarchical organization in the phase and frequency domains that is consistent with a deterministic mechanism of fibrillation.
The 9-mer Bid peptide also interacted with the G-loop and the HRD domain, that is consistent with substrate recognition and subsequent catalytic chemistry.
We have shown that, under the premise of a constitutive granularity of material entities, the current top-level categories of material entity of BFO are insufficient for developing domain ontologies that are consistent with the single inheritance policy.
Following this theory, in this article we propose a new data decorrelation approach where each defined fuzzyset would correspond to a "virtual retinal cone" that responds strongly at specific wavelengths of the hyper-spectral domain using models that are consistent with the human chromatic perception.
Moreover, protein protein interactions were detected using NMR chemical shift perturbation experiments between the RRM and GR domains of HvGR-RBP1, suggesting that at least in vitro, these two domains self-associate, results that are consistent with what has been observed for the Nicotiana tabacum NtGR-RBP1 protein.
The relative orientation of the domains is well defined, and is supported by the large number of inter-domain NOEs and by RDC values that are consistent with both domains fitting to a single alignment tensor (Supplementary Figure 7A).
Interestingly, multi-domain architectures tend to combine pre-existing domains, rather than to create novel domains, a point that is consistent with previous studies [ 4, 11, 18, 20].
Amino acid changes are present in major epitopes located in the P2 domain, a finding that is consistent with observations from previous epidemics (3 ).
