This is particularly true for raft-preferring lipids ("raft lipids", e.g. sphingolipids and sterols), whose domain preference is a strict function of their molecular architecture, and is thus susceptible to disruption by fluorescence labeling.
Moreover, a specific R-domain affinity was observed for miRNA in silico interaction toward LRR/NBS/TIR, which may indicate to some extant a domain preference for R-gene/miRNA interaction.
The strategy of utilizing an isolated fingers/palm construct to reveal the intrinsic domain orientation preference is, however, subject to the limitation that inter-domain interactions involving the thumb and connection domains are omitted.
While this means that consideration of relative domain preferences does not significantly change the results at the group level, as the authors confirmed, it might be important at the individual level of analysis.
We also investigated the domain arrangement preference and the domain family combination patterns in 'singlets' (single-spannings with one assigned domain) and 'doublets' (with two domains).
They also suggest that the plasmin-sensitive domains prefer the amphiphilic interfacial areas defined by PS PMMA and the bulk of the αC chains favors the PS block whereas the αC domains show a preference to PMMA.
Unlike the D domain, the DEF domain shows preference for ERK compared to JNK or p38 [ 40, 41].
In some cortical domains, phase preference at high spatial frequencies remained constant through >1 mm of cortical depth.
AccA2 contains an N-terminal BC domain and a C-terminal BCCP domain and AccB/PccB contain CT domains with preference for acetyl-CoA/propionyl-CoA as substrates.
Drawing on methods from conversation analysis and linguistics, I show that the status of hai x as a pre-request is reflected in particular properties in the domains of preference and sequence organisation, specifically in the design of blocking responses to the pre-request, and in the use of go-ahead responses, which lead to the expansion of the request sequence.
