The domain of complexity lacks clarity and the conceptual framework needs to be simplified and strengthened as till date most of the issues/concepts relating to this domain remain unexplored.
In addition, CCC v2 also includes a domain of complexity arising from dependence upon medical technology (device), and a domain indicating having received transplantation.
Def1 is an unusual protein, consisting largely of domains of low complexity, with a predicted N-terminal CUE (ubiquitin-binding) domain as the only notable feature (Ponting, 2002).
It is possible that distinct phosphatase complexes could target γH2AX molecules located at different distances from DSB sites or could be associated with DSBs in chromatin domains of different complexity or could operate in certain cell cycle phases (Douglas et al. 2010).
One of these conserved proteins, Deide_15148, is predicted to contain a hydrophilic cytoplasmic domain of low complexity followed by a C-terminal transmembrane helix.
This paper describes mathematical fundamentals and practical implementation of a powerful method and algorithm allowing transformation of multiply connected domains of arbitrary geometrical complexity into a set of simple domains; the latter can then be processed by broadly available finite element mesh generators.
Proteins contained in P bodies or stress granules are characteristically composed of two types of domains: RNA-binding domains (RBDs) and domains of low sequence complexity; the latter are also referred to as prion-like (Gilks et al., 2004; Decker et al., 2007; Reijns et al., 2008; King et al., 2012; Malinovska et al., 2013).
Many nucleoporins contain domains of low sequence complexity, which are compositionally similar to yeast PDs and form a sieve-like matrix that enables the selective passage of cargo complexes (Frey et al., 2006; Frey and Gorlich, 2007; Hulsmann et al., 2012).
In order to reduce the impact of this threat, we made our best effort in: (i) selecting an heterogeneous set of systems in terms of domain, complexity and degree of architecture decay, and (ii) selecting systems with varied types of architectural problems and code anomalies.
The fact that the α-CA we have identified here has a significantly different domain of low-complexity from previously described shell-associated α-CAs suggests that this gene may have a different evolutionary history.
