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Hai, R. et al. Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes.
Grizot, S. et al. Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds.
Single domain antibodies are recombinantly expressed variable domains derived from camelid heavy chain antibodies.
These results were replicated using purified recombinant I domains derived from integrin α1 and α2 subunits.
In addition, specific cell wall binding domains derived from endolysins are exploited for the development of diagnostics.
Aflibercept has two inherent functional properties; it binds VEGF via VEGF receptor subunits fused to the N-terminal end of each of the Fc heavy chains, and to Fc receptors via constant Fc domains derived from human IgG1.
Furthermore, the lead ligand exhibits selectivity against SH3 domains derived from other Src kinases, in spite of a sequence identity of approximately 80%.
Specifically, we use a biomimetic engineered extracellular matrix (eECM) that contains modular protein domains derived from two ECM proteins found in the small intestine, fibronectin and elastin.
Single domain antibodies, recombinantly expressed variable domains derived from camelid heavy chain antibodies, are often expressed as multimers for detection and therapeutic applications.
These results suggest that COOH- and NH2-SAMs allow for both cell adhesion and cell spreading because of the high density of cell-binding domains derived from adsorbed Vn.
The protein is lenercept, an immunoadhesin comprising the Fc domain of human IgG1 and two tumor necrosis factor (TNF) binding domains derived from the extracellular portion of the TNFR1 p55).
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