Sentence examples for domain to regulate from inspiring English sources
Smad7 also binds to DNA through its MH2 domain to regulate transcription (Yan and Chen, 2011).
Here, we report that scaffold attachment factor A (SAF-A), originally identified as a structural nuclear protein, interacts with chromatin-associated RNAs (caRNAs) via its RGG domain to regulate human interphase chromatin structures in a transcription-dependent manner.
The CXXC domains are important for TET proteins binding to specific genomic regions for their action (Xu et al., 2012; Tan and Shi, 2012; Jin et al., 2014), and they can cooperate with the catalytic domain to regulate the key gene expression (Xu et al., 2012; Ko et al., 2013).
One surface docks against the catalytic DH domain to regulate GEF activity and the another binds proteins containing PPII helices, perhaps for cellular targeting.
Here, we have analysed a conditional Jag1 mutation in the developing spinal cord and confirmed that Jag1 is necessary in the V1 domain to regulate neurogenesis.
We would like to thank Anthony Capobianco for his suggestion to use the estrogen receptor hormone-binding domain to regulate the transcriptional activator and for providing the construct.
PTPN11 uses its amino-terminal SH2 domains to regulate activity and to increase concentration in specific cellular compartments.
Alternatively, the intracellular membranes may be permanently attached to the tight junction domains to regulate local activities such as calcium release from intracellular stores.
bHLH proteins act as obligate dimers binding DNA through composite basic domains to regulate the transcription of target genes containing E-boxes (CANNTG) in their promoters.
This Rpn10 fraction can engage the polyubiquitin receptors Rad23 and Dsk2 through an interaction between their respective UIM and UBL domains to regulate the accessibility of these receptors to the proteasome [ 26– 28].
Such a transcription factor might be either a native protein or a protein engineered using zinc-finger or TALE DNA-binding domains to regulate expression of either native or exogenously introduced genes.
