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Tertiary structure predictions were generated using Swiss-Model [ 50] using known crystallised TLR structures of highest similarity: extracellular domain template 2a0zA and TIR domain template 1fyvA.
First of all, all threading tools have a similar internal workflow, comprising preprocessing, two main tasks performed against chain and domain template libraries, and postprocessing tasks.
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Benetos and Dixon [11] observed that, in the constant-Q transform (CQT) domain, templates assigned to different notes are equivalent to shifting other templates in the frequency domain.
Step II: Clustering the discontinuous domain templates.
The discontinuous domain templates are clustered based on their domain boundary locations and domain assignments.
The array coefficients are calculated by matching the measured HRTFs with a frequency-domain template.
Furthermore, oriented PEO domains template oriented ZnO domains and wormlike morphologies direct wormlike ZnO nanostructures.
These segments are highly consistent with the first cluster of discontinuous-domain templates that have a domain structure of (27 104 247 454) (105–27 104 247 454
To calculate the P-value, we use a set of reference templates, which consist of ∼1800 single-domain templates with different SCOP folds.
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In the case of polymorphic toxins the domain architecture template is defined by the presence of multi-domain proteins, wherein the C-terminal-most domain has toxin activity, while the N-terminal-most domains are associated with trafficking (Table 1, Figure 1).
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