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In the frequency domain, surface wave analysis usually requires many fewer data samples than in the time domain.
The experimental results can be explained in terms of the normal mobility with respect to the domain surface, which is reduced by a factor representing the domain aspect ratio estimated to be 300 for considered wire samples.
Intermolecular CH2-CH2 domainteractionsons partially bury the CH2 domain surface that would otherwise be exposed by the absence of oligosaccharide, and two Fc molecules are interlocked in a symmetric, open conformation.
These ligands bound the SH3 domain with ca. one and a half to twofold reduced affinity relative to 2-aminoquinoline; however, some evidence was found to suggest that the benzylic substituents made new contacts with the SH3 domain surface.
The native residues, both arginines, are solvent accessible, and their mutation will directly impact upon the electrostatic property of the GS domain surface.
The color spectrum mapped onto the domain surface ranged from −7 kT/e (dark red) to +7 kT/e (dark blue).
Similar(21)
To understand the potential role of LGI1 glycosylation we analyzed their distribution over the domain surfaces.
10.7554/eLife.00828.015 Figure 8. Ala scan for HECT domain surfaces required for di-Ub synthesis.
Indeed, synthetic rewiring of signalling pathways is challenging because of our limited understanding of how to engineer novel complementary protein or domain surfaces with the desired functionalities.
Expression was improved by substituting a serine for a phenylalanine residue on the Fv-domain surface.
The selected peptide mimics a discontinuous epitope, a peculiar shape on the CD11b-I-domain surface.
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