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Lisa was best known, however, for her sweeping books that took detailed, and ever-so often sometimes dull, academic debates into the public domain, rendering these issues exciting and accessible.
Data scientists are typically attached to technology firms, and are therefore disproportionately likely to analyse and visualise data that is not in the public domain, rendering it unavailable for interested parties to attempt to reproduce results or carry out analyses of their own.
Most cancer-associated p53 mutations occur within the DNA-binding domain, rendering the proteins as defective tumour suppressors.
It is possible to mutate one nuclease domain, rendering Cas9 capable of cleaving only one DNA strand.
Y699F-STAT5b cannot be phosphorylated on the conserved tyrosine residue Y699, and dn-STAT5b lacks the C-terminal transactivation domain, rendering these constructs transcriptionally inactive [ 14, 17, 20].
The three S. mansoni RGC proteins have an amino acid substitution in the aspartic acid in subdomain VIb of the catalytic domain, rendering them catalytically inactive.
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Action also takes place in the virtual realm of QuestWorld, a three-dimensional cyberspace domain rendered with computer animation.
Deletion of this domain renders certain substrates insensitive to proteolytic cleavage.
In a previous study, the attachment of chromophores to this QBP binding domain rendered the resulting chimeric protein sensitive to arginine, but not to glutamine [23].
DNA binding by TIEG1 was shown to be essential for this activation since deletion of the zinc-finger containing domain rendered this protein inactive on the Runx2 promoter (Figure 5B).
However, it has been both assumed and also reported that the removal of the R domain renders the resultant truncated "receptorless" DT incapable of binding to and being internalized by cells.
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