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The conformational change in Bax results in the globular domain remaining in the cytosol and sterically prevents oligomerization perpendicular to the membrane [60].
Alignment of the four classes of ACBPs in our study confirmed ACBD as the only common domain; remaining amino acid residues had no similarities.
Thus, the VDR DNA-binding domain acts (through heterodimerization with RXR) in keratinocytes to promote hair growth without requiring binding of vitamin D. This phenotypic domain specificity also occurs in mice, as Vdr KO mice had rickets but normal fur if the Vdr ligand-binding domain was disrupted with the Vdr DNA-binding domain remaining intact.
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In 1998, the Sonny Bono Copyright Term Extension Act passed, adding 20 years to the length of copyright, both pro- and retroactively, and ensuring that thousands of creative works poised to enter the public domain remained in private hands.
In contrast, helicase ATP-binding domain remained conformationally stable throughout simulations.
The domain of complexity lacks clarity and the conceptual framework needs to be simplified and strengthened as till date most of the issues/concepts relating to this domain remain unexplored.
Still, the pedagogical values of Facebook in formal learning domain remain inconclusive, and studies have reported a mixed attitude and views of using Facebook for learning purposes among students (Manca & Ranieri, 2013).
In contrast, the size of the highly sulfated domain remained relatively stable regardless of chain length.
In contrast, GFP alone and fusion proteins lacking the proline-rich domain remained in the supernatants (Figure 4F).
Specifically, the short fragment of Pak1 containing the NLS sequence (residues 226 249), when fused to FKBP in place of the LC8 binding domain, remained cytosolic despite being unencumbered by steric restraints from the remaining domains of wild-type Pak1.
Despite extensive studies of PrP variants bearing mutations of the octarepeat region, understanding of the properties of this domain remain unclear.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com