Halt relocation, execute queries, resume relocation.
There is a mitochondria-targeting segment in the SDR domain, which allows relocation of WWOX/WOX1 to the mitochondria [ 1- 3, 8].
Also, sex steroid hormones estrogen and androgen may interact with an N-S-Y-Kmotif in the SDR domain that allows relocation of WWOX/WOX1 to the nucleus [ 3, 7].
For instance, the lncRNAs Kcnq10t1 promotes the lineage-specific inhibition of genes in the Kcnq1 domain by inducing their relocation to the nucleoli [ 149, 150].
Quantitative analysis of subnuclear localization induced by Dot1 targeting suggests that Dot1 contributes to derepression by promoting the relocation of a domain away from the repressive environment at the nuclear periphery.
We dissected the functional domains of Uhrf2 and found that the TTD, PHD and SRA domains are important for the relocation of Uhrf2 to the sites of DNA damage.
For instance, the differentiation of hematopoietic progenitors into either erythroid cells or neutrophils is associated with differential spatial relocation of chromosome domains in the two cell types, which relates to differentially expressed genes [ 22].
Further examination of the effect of GC content, protein domains, expression level and gene relocation, would clarify the relation between functional bias and other factors that correlate with divergence rate.
In P. falciparum, relocation to another 'active' domain, still in the nuclear periphery, is believed to contribute to the switching and the activation of VAR genes [ 7, 33].
This key conformational change also instigates the relocation of the DNA-binding domain, with concomitant smaller changes in the ligand-free subunit resulting in a QacR structure no longer able to bind to the IR1 operator site [3], thus allowing up-regulation of qacA transcription.
