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On closer investigation of these sites we find that 12/45 positively selected sites occur in the disintegrin domain (position 384-473).
The head domain position of the mature 30S subunit as a reference is shown in (G) as a red oval labeled with "m".
The head domain position of the II-e-4 map is not given in (G) since it has extremely low density in the head domain region.
Chromatin domain position is established early in G1 [17], [17] and appears to be stable during most of interphase [9].
Indeed, when we superimpose PDZ domain binding affinities with gene ontologies, network topology data and the domain position within a PDZ superfamily protein, functional overlap is minimized and PDZ domains position optimally in the binding space.
To analyse whether the contribution of motif- and context-binding residues to the binding energy in the globular domain differs, we computed the "context binding fraction" for each domain position, that is, the ratio of context contacts vs. all interchain (i.e. motif plus context) contacts observed for this residue.
Similar(29)
The overall dimeric structure of PcaD reveals an α-helical cap domain positioned atop a core α/β-hydrolase domain.
A MIF4G domain positioned centrally within the Not1 protein recognizes Caf1, which in turn binds the LRR domain of Ccr4 and tethers the Ccr4 nuclease domain.
In addition, the structure of most of the inter-domain linker allows us to propose relative domain positions for sACE that may contribute to the domain cooperativity.
We conclude that 3D-FISH is a useful tool to study chromosome territory structure and arrangements down to the level of ∼1-Mb chromatin domain positions.
The increase in molecular organisation can be attributed to (i) sharpening of phase boundaries, (ii) annealing of domain positions, and/or (iii) increasing the contrast by material moving between domains.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com