For the impact of symptoms on patients' daily lives, there were no substantial differences in the domains of impact experienced by patients with ACO or COPD (Fig. 2).
Our findings demonstrate that there were no substantial differences in the symptoms or domains of impact experienced by patients with ACO or COPD alone.
We aimed to understand and compare the patient experience of symptoms and domains of impact in ACO relative to COPD, and assess the content validity of existing patient-reported outcome (PRO) instruments in ACO.
Taking "positive health" as a focus, TIDS have three domains of impact: (1) subjective (e.g., feeling great), (2) biological (physiological capacity), and (3) functional (being productive in daily life) [13].
This open-ended section was designed to elicit concepts that arose spontaneously from the respondents, without suggestions from the interviewer regarding possible domains of impact.
The more so because generic questionnaires lack specific domains of impact on parental burden, such as 'social support' and 'contact with caregivers'.
The symptoms and domains of impact reported by patients during the open-ended part of the interviews were mapped onto the LPH items to assess content validity of the LPH.
This covers global health and eight main domains of impact on the child and family respiratory symptoms, ear problems, reported hearing difficulties, speech and language, sleep patterns, school prospects, and parents' quality of life.
Mapping the symptoms and domains of impact elicited from the patient interviews on to the LPH items indicated that key symptom concepts relevant to PAH are assessed by the LPH.
Thus, the TRIM-Diabetes/Device are valid and reliable PRO measures to assess the total impact, as well as the specific important domains of impact, some of which more closely represent an HRQoL domain (e.g., Daily Life), while others treatment satisfaction domains (e.g., Treatment Burden), or treatment behavior (Compliance).
