For forced dimerization of the Cre fragments, we selected a yeast interaction domain to decrease the risk of interaction with endogenous murine coiled-coil proteins.
Such behavior could be predicted via Fig. 1, which shows that the existence domain of solitons decreases with a decreasing f.
Another option is to design digital signal filters in the frequency domain to decrease the autocorrelation of the time series.
Deletion of N-terminus domain of EcBirA decreases binding affinity of the enzyme by ∼100 fold [29].
This argues that removal of the region C-terminal to the HMG domain of Sox2 decreases its association with Sall4.
Sindbis virus overexpression of the catalytic domain of SENP1 decreased AMPAR EPSCs only in cells treated with TTX.
For example, the immunoglobulin-binding protein A (IbpA) of Histophilus somni contains a direct repeat of two Fic domains, and mutation of IbpA or just the fic domain of IbpA decreased the virulence of this bacteria.
Ligation of the cell surface GRP78 in teratoma cell line (NCCIT) and breast cancer cell line (MCF-7) with antibody directed against the N-terminal domain of GRP78 decreased cell proliferation and cell adhesion by inhibiting MAPK/PI3K signaling pathway [ 16, 17].
Limiting the correlation analysis only to the internal nodes results in 25 31% of domains increasing in size versus 12 19% of domains decreasing in size.
In addition to altering the relative stability of monomeric and domain-swapped dimeric forms, light has a dramatic effect on the kinetics of domain swapping, decreasing the half-life from weeks to minutes.
Chondrocyte apoptosis induced by aggrecan G1 domain as a result of decreased cell adhesion.
