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The atypical perpendicular orientation of its two fibronectin domains explains the lack of C domain involvement in ligand binding.
In many cases, the functional significance of this architecture is unknown, and there are several cases in which evidence for individual domain involvement in adhesion has been contradictory.
Studies on oligomer formation in GPCRs has largely focused on the involvement of either full-length receptors or the transmembrane regions with very few reports of extracellular amino-terminal domain involvement [37] [39].
10 Organ domain involvement by BILAG was defined as an A or B score.
In the SELENA SLEDAI analyses, all patients with vascular domain involvement had vasculitis.
Given the structural homology between ERs and ERRs, particularly in the DNA-binding domain, involvement of ERRs in estrogenic signaling pathways is not unexpected (Giguère 2002).
Similar(48)
Foxall (1995) proposed that consumer choice is shaped by adaptive innovative cognitive style [Kirton, 1976. Adaptors and innovators a description and measure. Journal of Applied Psychology 61 5), 622 629] and product-domain involvement [Zaichkowsky, 1985. Measuring the involvement construct. Journal of Consumer Research 12(341 352]341 352]
The most likely explanation for this multi-domain involvement is that structural, rather than enzymatic features of N-AChE-S protein are involved.
Exploring the importance of the number of CRM domains and involvement of each CRM domain in substrate recognition during intron splicing and rRNA processing should provide a much deeper insight into the mechanistic role of CRM family members in chloroplast RNA metabolism.
The domain "Stakeholder involvement" (four items) focuses on the extent to which the CG reflects the views of its intended users and affected patients.
However, dissection of the JM autoantibody response to individual epitopes reveals a more complex influence of the HLA region on the specificity of autoimmunity to the JM domain, with involvement of both HLA-DR and HLA-DQ alleles.
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