Exact(4)
Chk1, checkpoint kinase 1; FADD, Fas-associated death domain; FISH, fluorescence in situ hybridization; Pak1, p21-activated kinase 1.
CA = cancer antigen; ELISA = enzyme-linked immunosorbent assay; ECD = extracellular domain; FISH = fluorescence in situ hybridization; FDA = Food and Drug Administration; HER = human-epidermal-growth-factor receptor.
2DBD-NR: nuclear receptor containing two tandem DNA binding domains, BAC: bacterial artificial chromosome, DBD: DNA-binding domain, FISH: Fluorescent in situ hybridization, LBD: ligand binding domain, NR: nuclear receptor, WGS: whole genomic sequence.
CISH: chromogenic in situ hybridization; ER: estrogen receptor; CGH: comparative genomic hybridization; Chk1: checkpoint kinase 1; FADD: Fas-associated death domain; FISH: fluorescence in situ hybridization; HNSCC: head and neck squamous cell carcinoma; ICC: immunocytochemistry; IHC: immunohistochemical; LOH: loss of heterozygosity; PR: progesterone receptor; RFS: recurrence-free survival.
Similar(56)
In contrast to these approaches, computational prediction of compounds and their targets (target deconvolution) has involved ligand similarity using Bayesian methods as a domain fishing model [28] and other methods [29].
Whenever a domain was exclusively identified by the Domain Fishing Server, that domain was then manually excised from the longer proteins.
The resulting trees were similar to those shown in the Figures 1 and 4. Multidomain proteins were identified using the Domain Fishing server [ 49] and PROSITE [ 50].
Of all the C1q-domain containing proteins, mouse Otolin shares the highest degree of amino acid identity (52%) in the globular domain with fish sacullar collagen [47], a protein found only in the inner ear of fish (Fig. S2).
The SAM domain of fish STIM-2a/b molecules might have evolved differently or land vertebrates regained the conserved module by convergent evolution after diverging from fish species.
In CCAR1, structural flexibility has increased in the SAP domain from fish to amphibian, The NLS domain had a sudden decrease in structural flexibility from mammals to Therapsida, before increasing from primate to human.
We have previously shown that the kinase domain of fish PKZ is more closely related to that of mammalian and chicken PKR than to the other eIF2α kinases [ 19].
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