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About 25% of UniSeqs matched a protein domain entry in the Pfam database [ 42].
The PFAM-A seed alignments (7) provided a suitable framework for establishing a database that comprised a catalogue of the evolutionary rate at codon sites for each protein domain entry.
HECT amino acid sequences were retrieved with a HMMER search, using the HMM profile of the Pfam HECT domain entry (PF00632) as a query, the default parameters and an inclusive E value of 0.05.
If we assume that after EGFR dimer activation domain entry is a random partition process, then the domain occupancy distribution will be a Poissonian aggregate distribution and the equilibrium distribution between domain and nondomain sites will be given by a simple linear partition function.
Similar(55)
The transmission delay in the backbone between any two domain entries is assumed to be a small value δ, since the transmission delay in the fiber backbone is very low.
Protein domain and boundary information for each of the 11,128 proteins in the dataset was determined by sequence similarity search against domain entries in Structural Classifications of Proteins (SCOP) version 1.69 [32], at the e-value cut-off of 10−3.
Conversely, more general InterPro family and domain entries may be annotated with a more general GO term, subject to meeting evidence requirements.
More specific family or domain entries, located at the leaf nodes of InterPro hierarchies (and which therefore might only describe a few well-characterized proteins) may be annotated with a correspondingly specific GO term.
The cluster file was loaded onto Treeview (version 1.60; http://rana.lbl.gov/EisenSoftware.htm) to generate a 2D branched-tree image including the phylogenic order of proteins and domain entries.
Each domain's entry includes selected additional information about it, including the domain's registrar, partial WHOIS data, and a categorization of the content posted on the domain's web site or post-redirection target.
From our perception of the extractors as a whole, ReVerb and DepOE were designed to work with a much larger and multiple domain data entry.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com