A second simulation solves a test problem that models radiation transport in a domain comprised of materials with different refractive indexes.
Their molecular architecture features a catalytic domain, unrelated to that of all PKC family members, and a large inhibitory, regulatory domain, comprised of two Zinc fingers, and a pleckstrin homology domain.
By using chromosome transfer, we revealed that de novo activation of a silent PRF1 locus was controlled by a 150 kb domain comprised of 16 DNase I hypersensitive sites (DHSs).
The TPR domain is a protein-protein interaction domain, comprised of a loosely conserved 34 amino acid sequence that is repeated several times [7].
The N-terminus of EBNA1 consists primarily of a 239-amino acid domain comprised of a Glycine-Glycine-Alanine (GGA) repeat region.
Early studies showed that pp32, through a specific domain comprised of ∼25 amino acids, acted like a tumor suppressor by inhibiting K-ras, a mutant p53, c-jun, E1A, E6, and E7 [13], [13].
The structure of the human heterodimeric Sae1-Uba2 complex that comprises the Sumo E1 [19] displays conserved E1 domains [27], [28]: a heterodimeric "adenylation" domain comprised of portions of both Sae1 and Uba2, a domain of Uba2 containing the E1 catalytic cysteine, and a C-terminal ubiquitin-fold domain (ufd) from Uba2 that structurally resembles ubiquitin and Sumo [29].
PC-1 has a very large extracellular domain comprised of a novel combination of protein-protein interaction domains, 11 transmembrane domains and a short intracellular C-terminus containing a coiled-coil motif that mediates an interaction with the PKD2 gene product, Polycystin-2 (PC-2) [2] [3].
The Nek8 RCC1 domain comprised of 6 identifiable RCC1-like repeat domains (Additional file 3: Figure S2).
Talin contains an N-terminal FERM domain (comprised of F1, F2 and F3 domains) and a C-terminal flexible rod.
