Conversely, other studies suggest a correlation between the ability of Dsh proteins to bind Fz receptors, possibly via the PDZ rather than the DEP domain, and the ability to mediate canonical signaling (Umbhauer et al. 2000; Wong et al. 2003; Cong et al. 2004; Wu et al. 2008; Tauriello et al. 2012).
As such, the scoring system was developed to capture both the image quality of the individual views (Image Generation domain) and the ability of an expert to make a clinical judgment based on the images provided (Image Interpretation domain).
Templates embody the expert's knowledge on the domain and his/her ability to understand and answer questions, but designing these templates may become a complex task since it is usually carried out manually.
In addition, we generated variants lacking both the WRPW domain and the ability to bind DNA (RR→AQ mutations), which we named cHES6-1AQΔWRPW and cHES6-2AQΔWRPW.
This is particularly interesting because MGAS5005 has been shown to produce a truncated, functionally inactive CovS protein, which results in a loss of the histidine kinase domain and the ability to phosphorylate CovR [48], [54], [55].
The pacsin3 morphant phenotype of a stunted body axis and contorted trunk is rescued by ectopic expression of Drosophila Syndapin, and depends critically on both the prong that protrudes from the surface of the bowed Syndapin EFC domain and the ability of the antiparallel dimer to bind tightly to phosphoinositides.
The connection between the phosphoinositide-binding capacity of the PX-BAR domain and its ability to influence macropinosome formation was further investigated by modulating the levels of PI 3,4,5 P3, which has been localized to the macropinocytic cup very early in the formation process [31].
This dE2F1 mutant lacks both the transactivation domain and its ability to bind Rbf1.
Formation of FGs requires FUS N-terminal prion-like domain and the ability to bind specific RNAs.
The healthcare domain, and its ability to implement and diffuse innovations has generated intense scientific interest (for reviews see [ 4, 5]).
