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Recently, another non-cysteine amino acid substitution, L1515P, has been described in a French patient with cerebral small vessel disease lacking granular osmiophilic material deposits, and Notch3 extracellular domain accumulation.
We suggest that although subcellular domains or lipid platforms may increase local concentrations to enhance oligomerization our data clearly does not support a simple domain accumulation model of activated dimers in the absence of higher-order oligomerization.
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Although the function shift analysis does not take into consideration sites for which one of the groups has a full gap (as the 25 AA insertion/deletion in the C1 domain), the accumulation of these shifted sites throughout the RIFIN sequences resulted in the prediction of a function shift between A- and B-type RIFIN proteins.
This report emphasizes and briefly discusses important differences between the RNA expression pattern and the domains of accumulation of the protein.
Charge excitations (domains or accumulation layers) propagate from the cathode through the active region of the specimen and generate current or voltage pulses when they are discharged at the anode, or in some cases, they may be transformed into the stationary anodic domains [1, 7, 8].
Most basin fill was dissected during drainage integration within the upstream Gila domain but continued accumulation of undissected basin fill by sediment aggradation is dominant in the downstream Gila domain.
Charge accumulation (domain) results in across one well at a time, and each of the steps observed in the PC signal will be due to consecutive carriers escaping from the well [22].
Like with SasC, the domain conferring biofilm accumulation is located within the N-terminal domain (A domain), which also includes the domain for Fg-binding.
In order to evaluate the contribution of protein interactions mediated via the AMD domain to mADPR accumulation, a PARP mutant lacking the entire AMD domain, PARP-dAMD, was generated.
Disruption of this domain results in accumulation of Sec61β in large cytoplasmic puncta [55], [56], while N-terminal fragments of Sec61β devoid of the TMD are unable to complement any known function of the protein in S. cerevisiae [27].
Increasing MuSK protein expression via transgenesis broadens the domain of AChR accumulation and nerve growth, which has led to a model by which MuSK determines where future synapses form [16].
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