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However, polyadenylation efficiency does not strictly depend on the hexameric signal: "strong" sites may contain variant AGUAAA signals while "weak" sites may contain canonical AAUAAA hexamers.
These results indicate that centriole biogenesis does not strictly depend on SAS-6 self-assembly, and may require preexisting centrioles to ensure structural accuracy, fundamentally deviating from the current paradigm.
Thus, Pins/LGN does not strictly depend on forming a complex with Dlg for apical-basal spindle orientation in neuroblasts, even though this complex has an essential role in epithelia and other systems [ 20, 25 27].
The immortalization process is delayed accordingly, suggesting that it does not strictly depend on the number of cell doubling or the time that the cells spend in culture (45 culture days in this case).
Our finding that caspase-14 has been deleted in cetacean species, which have filaggrin, indicates that filaggrin does not strictly depend on neither direct nor indirect processing by caspase-14, at least in water-living mammals.
These analyses indicate that nucleotide binding within D1 is essential, whereas ATP hydrolysis appears not to be required or does not strictly depend on the glutamate residue in the Walker B motif, suggesting a predominantly structural function.
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Our results showed that USP25m catalytic activity did not strictly depend on the UBDs, but required a coiled-coil stretch between amino acids 679 to 769.
Alternate possibilities that circumvent the inherent inconsistencies associated with the above models but do not strictly depend upon random genetic or epigenetic changes for initiating tumorigenesis has also been articulated (Kauffman 1971; Potter 2001; Laforge et al. 2005; Huang and Ingber 2007; Brock et al. 2009).
Although our within-subject approach does not strictly require a control group, we wanted to ensure that any effects do in fact depend on amyloid-β pathology.
This assumption is convenient but does not strictly apply.
The experimental results indicate that the alloy does not strictly follow UO model behavior.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com