Additionally, their implementation is relatively easier than other types of pseudo-spectral methods since they do not require ad hoc collocation point distributions.
As reported by other authors, more simplified PRP preparation methods which do not require ad hoc and costly equipment would help in accumulating clinical data and in introducing the method more routinely in clinical practice as also in the operating room [ 17].
We would like to emphasize that our analytical approach does not require ad-hoc hypotheses as it would be the case if we were to model data coming from trans-stimulation and chloroquine efflux experiments where parameters such as the rate of the vacuole pH equilibration during chloroquine uptake or the kinetic constants of chloroquine-hemozoine binding are unknown.
Nevertheless, because of this, they do not require ad-hoc and expensive experiments, but can rely on the huge amount of publicly available transcriptional, chemoinformatics and literature-derived data, from which similarities and corresponding drug networks can be inferred.
The proposed solution is regular, scalable and does not require any ad hoc parameter tuning, e.g., depending on the experienced average SNR or the actual channel realization.
Next we discuss how both of these issues can be addressed in practice, the first by defining a form of mutual information that is naturally continuous and therefore does not require an ad hoc discretisation step and the other addresses the case where, in a naturally discrete system numerical artefacts resulting in divergences can be avoided.
Still, master-worker pattern simplifies the design because it implements a transparent dynamic load-balancing strategy and does not require any ad hoc rebalancing strategy.
The numerical method is based on the side-centered arrangement of the primitive variables that does not require any ad-hoc modifications in order to enhance pressure coupling.
But easy answers are hardly ever right answers, and post hoc does not require propter hoc.
The mechanism proposed here explains all the data we have obtained so far, and, quite significantly, its simple process does not require any new ad-hoc cytological mechanism, since all the proposed steps have been observed many times in closely related stick insects.
