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We corroborated this finding by demonstrating that mutation of key αRIM-2 residues abolished AMP-dependent, but not ATP-dependent, regulation of AMPK, indicating that ATP does not predominantly signal through αRIM-2/CBS-3.
In contrast, the same two mutations did not affect the ability of ATP to weaken the AID-αRIM interaction with the core complex, indicating that ATP does not predominantly signal through CBS-3/αRIM-2.
The alkaline comet assay does not predominantly measure the lesions (double-strand breaks) that are believed to be the cause of cell mortality – although a small component of the DNA breaks would have been double – rather it measures mainly single-strand breaks and alkali-labile sites.
According to rule 166: <94> FOS.in.off, TIMP1.in.on, SMAD7.out.off → TGFB1.in.on, MMP1.out.on, TGFB1.out.on and rule 188, the expression of MMP1 may also be induced in the absence of FOS (e.g., by JUN-containing AP-1 complexes), indicating that the regulation of MMP1 does not predominantly depend on FOS as proposed in the literature [ 17, 60].
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New York is well known for its subway system, but this week the New Yorker shone a light on a less-heralded form of transport: the city's "dollar vans", the unofficial shuttles that operate where the subway and buses do not, predominantly in low-income urban neighbourhoods.
Results suggest that they did not predominantly relocate their labour supply to bottom-paid occupations: while non-graduate middle workers move towards bottom occupations, graduate middle employees shift towards top occupations.
These results support recent reports that changes in DNA methylation do not predominantly occur in promoter regions or CpG islands [36].
Finally, our results may not be generalizable to MRSA clones that do not predominantly colonize the anterior nares.
In fact, ectopic-expression of FoxN1 in tissues that do not predominantly express FoxN1, such as the BM, is harmful.
Since C-terminally tagged dPob protein did not predominantly localize to the ER in vivo (data not shown), GFP-tagged EMC1 protein (EMC1 GFP) was used as the bait.
However, in contrast to seedlings and young petals, nuclei in fully matured petals do not predominantly contain 9 10 GFP dots but instead display a severe reduction in the number of centromeric dots (Fig. 7m).
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