For comparison, we show by NMR and circular dichroism spectroscopy that the G7K mutant of chignolin, in which formation of this misfold is impossible, is well folded with stability similar to the wild-type and does not populate the misfolded state in simulation.
This indicates that Ure2p N-terminal domain within its natural context does not populate a conformational state that incorporate within the amyloids that are generated when the prion domain is free in solution and out of its physiological context.
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For the C1-initiated simulations, which did not populate any C4-hemisphere puckers, increased sulfonation resulted in an increased population of C1-hemisphere envelopes and half-chairs.
Prior work has implicated the bHLH transcription factor Tal1 in endocardial tube formation: in zebrafish embryos lacking Tal1, endocardial cells form a disorganized mass within the ventricle and do not populate the atrium.
Chris Tillman, one of the Orioles' heralded pitching prospects, threw a no-hitter in Class AAA in April, but players the caliber of Alex Rodriguez and Cano do not populate the International League.
Although eosinophils typically reside in the lamina propria of the rest of the GI tract that is lined by a columnar epithelium, eosinophils do not populate the normal esophageal squamous epithelium.
Conformational replicators, whether prions or DNA computers, are quite different from synthetic replicators in that they "fall down" to the most stable state and do not populate multiple, intermediate states of roughly equal energy, which is what DNA helices with different sequences do.
It had not been fixed by Tuesday morning, however. 1 / Late last week, we discovered a technical issue that affected search results: searches for certain words related to sexuality did not populate complete results.
São Paulo is much less hilly than Rio, so when the great labour immigration from the northeast of the country accelerated from the 50s onwards, the new labour force did not populate the empty spaces right in the heart of the city by the coast as they had done in Rio.
Since most of these cells are newly generated and do not populate the CNS as densely as reported for Ng2+ cells in rodents (reviewed in [13]), it is likely that they represent immature cell progenitors trapped in the rabbit cerebellar cortex after pre/post-natal development, that continue to divide locally throughout life.
