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Actually, it is not critical if the SLS occasionally have a smaller dwell time, provided this does not occur too frequently.
In particular, arrestin-1 binding must be coordinated with phosphorylation so that it does not occur too quickly or too slowly.
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It is therefore particularly important to keep the number of pilot symbols in such schemes minimal, so that error floors do not occur too early.
In principle this not only suggests that East Asia has a parental genealogical relationship with America (as is known to be the case; see, for instance, [27]), but also that this did not occur too long ago, otherwise there would have been time for much higher levels of mutation-driven haplotypic diversification in Amerindians.
Clues do take longer to devise than normal, which is why PD puzzles don't occur too often.
The marvel is that on its five-hundredth birthday Brazil is still frisky enough to enjoy its Big Fashion Moment, because these Big Moments don't occur too often.
"For the colon to be functioning properly, it needs to be contracting and relaxing in a way that is conducive to regular bowel movements that occur at predictable times and don't occur too frequently or too rarely," Lebwohl says.
If the ratio is too low, sufficient cross-linking does not occur, affording a CLEA that is too flexible and unstable towards leaching in water.
Due to the fact that hydrolysis of SAH into homocysteine is required for DNA methylation (James et al. 2002), demethylation of 5-methyl-THF does not occur if vitamin B12 is too low (Bassler 1997).
The irony is lost on them, too: It does not occur to them that human rights apply as much to the guilty as to the innocent; that even the worst perpetrator deserves due process.
Identification of research gaps and promising solutions, as well as the documentation of tested, but failed approaches too often does not occur.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com