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The induction of this promoter is possible, but is not strictly required, because it does not involve a binding of tetracycline to a repressor protein as is generally reported in PTetA, a well-characterized, widely distributed promoter among Gram-negative bacteria (Butaye et al. 2003).
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These observations suggest that (1) FoxO1 is capable of recognizing non-canonical FoxO1 binding sites in some species, (2) FoxO1 regulates Agrp expression only in a subset of mammalian species, (3) or FoxO1 associates with Agrp upstream regions through a mechanism that does not involve a direct interaction with the putative FoxO1 binding sites.
"It doesn't involve a co-star.
These results did not involve an increase in milking duration.
Note that complex transformations do not involve any binding sites, therefore related edges point to the center of species nodes.
This effect was independent of RKIP expression, indicating that locostatin targets cytoskeletal elements through a mechanism that does not involve RKIP binding or inhibition of RKIP function.
The results described in this paper provide compelling evidence that good vanA activity is due to a mechanism of action that does not involve peptide binding.
None of the mutants displayed any defects in entry or colocalization with LAMP-1 (Fig. 5C), suggesting the infectious block of the cysteine mutants does not involve cell binding or intracellular trafficking.
Taken together, these data suggest that NUP98-HOXA9 modulatranscriptiontion by at least two mechanisms: one, exemplified by the KBTBD10 promoter, involves direct binding to the promoter through the homeodomain; while the other, exemplified by the PLN promoter, does not involve DNA binding.
In further experiments, we show that BRD4 associates with acetylated p53 but that this association is not inhibited by JQ1 indicating that the protein protein interaction does not involve bromodomain binding of acetylated lysines.
The other, which does not involve integrin binding by P66, is slower and may rely more on the motility of the bacteria and interactions with the tissue matrix than on P66 integrins as seen in the intravascular stage.
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