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Since scirrhous carcinoma does not form bone, we expected low levels of BMP expression.
However, it is important to consider that the microenvironment of the adult bone is distinct from the embryonic sclerotome, and that without the proper scaffold the ADSC does not form bone, even in the adult (Lee et al., 2013).
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Moreover, unlike our previous cartilage study, which resulted in cartilage formation upon transplantation, these aggregates did not form bone in vivo (data not shown).
BMP-1 and -3 expression was not detected in any of the clones, whereas low levels of BMP-7 appeared to be expressed by clone 3. Because the primary spindle cell tumor did not form bone [17], it may be expected that the clones derived from it did not express high levels of BMPs.
Similarly, Sp7-deficient mice do not form bone due to a failure of osteoblasts to differentiate (Nakashima et al., 2002).
However, periodontal progenitors do not form bone or other mineralized tissues in routine tissue engineering applications without osteoinduction [ 2].
Although, in noninduced samples, ASC survived at the ectopic site for more than 8 weeks and they did not form bone, as seen in previous studies (Refs 45, 99, 100, 102, 105) (Table 1).
But, said Dr. Babak R. Ghalili, a New York periodontal surgeon who specializes in difficult cases, "there are so many modalities now in bone grafting and implant technology that you can find a solution for nearly every patient" who has a suitable medical history and is motivated to take care of the implant so plaque does not form and cause bone loss.
ALL does not form masses, but rather takes over the bone marrow and spreads to the lymph nodes, spleen and liver.
It is noteworthy that AdRFP alone, AdRFP/AdR-RXRα and AdRFP/AdR-RARα groups did not form any discernable bone masses.
The muscles transfected with pCAGGS-BMP-7 did not form cartilaginous tissue, bone, or calcified areas during the observation period.
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